Mice with alterations to specific endogenous genes can be produced by gene targeting in embryonic stem cells. The field has developed rapidly over the past decade, so that large numbers of mice with different gene deficiencies have been generated. Knockout mice provide an ideal opportunity to analyse the function of individual mammalian genes and to model a range of human inherited disorders. This powerful approach has also identified numerous examples of gene redundancy and has highlighted the need to consider metabolic (...) differences between man and mouse in disease modelling. More sophisticated gene‐targeting methods are now being used to introduce subtle gene alterations. In the future, more refined genetic analysis and genome, rather than individual gene, alterations will be achieved by incorporating site‐specific recombination into targeting strategies. Gene targeting could also make a contribution to improved protocols for gene therapy. (shrink)

[Open access] In this book symposium the author takes up questions from phenomenology, hermeneutics, ethical theory, and intellectual history raised by a group of scholarly interlocutors from a range of backgrounds. In the course of engaging with these issues, he discusses, inter alia, McDowell’s realism, Jonathon Lear’s work on the end of a world, Michael Oakeshott’s view of selfhood, Heidegger’s conception of Jemeinigkeit, Uexküll’s notion of Umwelt, and Gadamer’s hermeneutic conception of truth.

David Miller is the foremost exponent of the purist critical rationalist doctrine and here presents his mature views, discussing the role that logic and argument play in the growth of knowledge, criticizing the common understanding of argument as an instrument of justification, persuasion or discovery and instead advocating the critical rationalist view that only criticism matters. Miller patiently and thoroughly undoes the damage done by those writers who attack critical rationalism by invoking the sterile mythology of induction and justification (...) that it seeks to sweep away. In addition his new material on the debate on verisimilitude is essential reading for all working in this field. (shrink)

David Miller elegantly and provocatively reformulates critical rationalism—the revolutionary approach to epistemology advocated by Karl Popper—by answering its most important critics. He argues for an approach to rationality freed from the debilitating authoritarian dependence on reasons and justification. "Miller presents a particularly useful and stimulating account of critical rationalism. His work is both interesting and controversial... of interest to anyone with concerns in epistemology or the philosophy of science." —Canadian Philosophical Reviews.

Remarks to the effect that a correct answer depends upon a correct question —that from a misleading question there can result only a misleading answer—are common today. In fact, one might suspect that such common concentration on finding the right questions has something to do with what seems to be an uncommon lack of answers. This concentration on the importance of asking the right questions can be applied to the interpretation of biblical literature. For here, certainly, the questions asked are (...) often decisive. They guide the inquiry by setting the terms of the search and, in this sense, they determine at least the kind of answers that will be given. Further, they often disclose the presuppositions with which one is working. (shrink)

"In the first study of its kind, David W. Johnson's "Watsuji on Nature" reconstructs the astonishing philosophy of nature of Watsuji Tetsurō (1889-1960), situating it in relation both to his reception of the thought of Heidegger and to his renewal of core ontological positions in classical Confucian and Buddhist philosophy. Johnson shows that for Watsuji we have our being in the lived experience of nature, one in which nature and culture compose a tightly interwoven texture called "fūdo". By fully (...) unfolding Watsuji's novel and radical claim that this is a setting that is neither fully external to human subjectivity nor merely a product of it, this book also sets out what still remains unthought in this concept, as well as in the relational structure that underwrites it. Johnson argues that what remains unarticulated is nothing less than the recovery of a reenchanted conception of nature and an elucidation of the wide-ranging implications of a relational conception of the self for questions about the disclosive character of experience, the distinction between fact and value, and the possibility of a place-based ecological ethics. In an engagingly lucid and deft analysis, "Watsuji on Nature" radically expands our appreciation of twentieth-century Japanese philosophy and shows what it has to offer to a global philosophical conversation"--Provided by publisher. (shrink)

This is an in-depth study of J.G. Fichte’s philosophy of mathematics and theory of geometry. It investigates both the external formal and internal cognitive parallels between the axioms, intuitions and constructions of geometry and the scientific methodology of the Fichtean system of philosophy. In contrast to “ordinary” Euclidean geometry, in his Erlanger Logik of 1805 Fichte posits a model of an “ursprüngliche” or original geometry – that is to say, a synthetic and constructivistic conception grounded in ideal archetypal elements that (...) are grasped through geometrical or intelligible intuition. -/- Accordingly, this study classifies Fichte’s philosophy of mathematics as a whole as a species of mathematical Platonism or neo-Platonism, and concludes that the Wissenschaftslehre itself may be read as an attempt at a new philosophical mathesis, or “mathesis of the mind.” -/- “This work testifies to the author's exact and extensive knowledge of the Fichtean texts, as well as of the philosophical, scientific and historical contexts. Wood has opened up completely new paths for Fichte research, and examines with clarity and precision a domain that up to now has hardly been researched.” Professor Dr. Marco Ivaldo -/- “This study, written in a language distinguished by its limpidity and precision, and constantly supported by a close reading of the Fichtean texts and secondary literature, furnishes highly detailed and convincing demonstrations. In directly confronting the difficult historical relationship between the Wissenschaftslehre and mathematics, the author has broken new ground that is at once stimulating, decidedly innovative, and elegantly audacious.” Professor Dr. Emmanuel Cattin. (shrink)

Historically, nonclassical physics developed in three stages. First came a collection of ad hoc assumptions and then a cookbook of equations known as "quantum mechanics". The equations and their philosophical underpinnings were then collected into a model based on the mathematics of Hilbert space. From the Hilbert space model came the abstaction of "quantum logics". This book explores all three stages, but not in historical order. Instead, in an effort to illustrate how physics and abstract mathematics influence each other we (...) hop back and forth between a purely mathematical development of Hilbert space, and a physically motivated definition of a logic, partially linking the two throughout, and then bringing them together at the deepest level in the last two chapters. This book should be accessible to undergraduate and beginning graduate students in both mathematics and physics. The only strict prerequisites are calculus and linear algebra, but the level of mathematical sophistication assumes at least one or two intermediate courses, for example in mathematical analysis or advanced calculus. No background in physics is assumed. (shrink)

David Hume's writings on history, politics and philosophy have shaped thought to this day. His bold scepticism ranged from common notions of the 'self' to criticism of standard theistic proofs. He insisted on grounding understandings of popular religious beliefs in human psychology rather than divine revelation, and he aimed to disentangle philosophy from religion in order to allow the former to pursue its own ends. In this book, Professors David W Purdie and Peter S Fosl decipher some of (...) Hume's most challenging texts for the modern reader, while preserving the sharp intellect and undaunted nerve for which Hume is famous. Hume's spirit is brought alive for contemporary times and his writing is made accessible for its intended audience: the general public."-- Back cover. (shrink)

Attacks nothing less than the currently prevailing worldphilosophy--humanism, which the author feels is exceedingly dangerous in itshidden assumptions.

This book discusses the development of Edward Tolman's purposive behaviourism from the 1920s to the 1950s, highlighting the tension between his references to cognitive processes and the dominant behaviourist trends. It shows how Tolman incorporated concepts from European scholars, including Egon Brunswik and the Gestalt psychologists, to justify a more purposive form of behaviourism and how the theory evolved in response to the criticisms of his contemporaries. The manuscript also discusses Tolman's political activities, culminating in his role in the California (...) loyalty oath controversy in the 1950s. Tolman was involved in a number of progressive causes during his lifetime, activities that drew the attention of both state legislators in California and the Federal Bureau of Investigation. It treats Tolman's theoretical and political activities as emanating from the same source, a desire to understand the learning process in a scientific manner and to apply these concepts to improve the human condition. (shrink)

Fichte-Studien, volume 49 (Leiden: Brill/Rodopi Publishers, 8 April 2021), edited by David W. Wood, 471pp. -/- Presenting new critical perspectives on J.G. Fichte’s Wissenschaftslehre, this volume of articles in English by an international group of scholars addresses the topic of first principles in Fichte’s writings. Especially discussed are the central text of his Jena period, the 1794/95 Grundlage der gesammten Wissenschaftslehre, as well as later versions like the Wissenschaftslehre nova methodo (1796-99) and the presentations of 1804 and 1805. Also (...) included are new studies on the first principles of the particular sub-disciplines of Fichte’s system, such as the doctrines of aesthetics, nature, right, ethics, and history. The volume also contains a number of miscellaneous essays on Fichte research, as well as several book reviews. (shrink)

In our age of globalization, we need a theory of global management consistent with our common human nature. The place to begin in developing such a theory is the philosophy of traditional cultures. The article focuses on African philosophy and its fruitfulness for contributing to a theory of management consistent with African traditional cultures. It also looks briefly at the Confucian and Platonic-Aristotelian traditions and notes points of agreement with African traditions. It concludes that the needed theory of global management (...) should regard the firm as a community, not a collection of individuals, and should understand the purpose of management as promoting the common good. (shrink)

Within political theory there has been a recent surge of interest in the themes of loss, grief, and mourning. In this paper i address questions about the politics of mourning through a critical engagement of the work of Judith Butler. I argue that Butler's work remains tethered to an account of melancholic subjectivity derived from her early reading of Freud. These investments in melancholia compromise Butler's recent ethico-political interventions by obscuring the ambivalence of political engagements and the possibilities of achieving (...) and sustaining non-dogmatic identities. To overcome this impasse I argue for an alternative framing of mourning by turning to the psychoanalytic theory of Melanie Klein. An account of mourning that leans upon Klein's work cashes in on the ethical and political promises that are immanent yet unrealized in Butler's recent work while providing a new orientation for mourning in, and for, democratic politics. (shrink)

The interest in and enthusiasm for urban agriculture (UA) in urban communities, the non-profit sector, and governmental institutions has grown exponentially over the past decade. Part of the appeal of UA is its potential to improve the civic health of a community, advancing what some call food democracy. Yet despite the increasing presence of the language of civic agriculture or food democracy, UA organizations and practitioners often still focus on practical, shorter-term projects in an effort both to increase local involvement (...) and to attract funding from groups focused on quantifiable deliverables. As such, it seems difficult to move beyond the rhetoric of food democracy towards significant forms of popular participation and deliberation within particular communities. In this paper we provide a theoretical framework—deep democracy—that helps to contextualize nascent attempts at civic agriculture or food democracy within a broader struggle for democratic practices and relationships. We argue that urban agriculture efforts are well positioned to help citizens cultivate lasting relationships across lines of difference and amidst significant power differentials—relationships that could form the basis of a community’s collective capacity to shape its future. We analyze the theory of deep democracy through recent experiences with UA in Denver, Colorado, and we identify ways in which UA can extend its reach and impact by focusing more consciously on its political or civic potential. (shrink)

This paper explores the state of teacher training in philosophy graduate programs in the English-speaking world. Do philosophy graduate programs offer training regarding teaching? If so, what is the nature of the training that is offered? Who offers it? How valuable is it? We conclude that philosophers want more and better teaching training, and that collectively we know how to deliver and support it.

This paper defends the permissibility of stem cell research against a theological objector who objects to it by appealing to "souls.".

This paper attempts to reconcile two ideas that seem fundamentally opposed to one another: the reality of the self and the doctrine of no-self. Buddhism offers a form of spiritual equanimity that turns on the denial of a self. Nonetheless, there seem to be good reasons to hold onto the reality of the self. The existence of a self enables us to account for praise and blame, the hopes for oneself that motivate actions, and attachments to the selves of others (...) in bonds of love and affection. I show how it may be possible to reconcile the reality of the self with a particular interpretation of the no-self doctrine by engaging with the work of thinkers from the phenomenological tradition such as Merleau-Ponty, Zahavi, Gallagher, and Petitmengin. (shrink)

In lieu of an abstract, here is a brief excerpt of the content: I would like to begin by thanking the Journal of Japanese Philosophy for making space in these pages for a review of my monograph Watsuji on Nature: Japanese Philosophy in the Wake of Heidegger. Although book reviews do not usually receive a reply from the author—much less one as lengthy as the article that follows—one seemed necessary in this instance because my ideas, unfortunately, have been seriously mis-represented (...) here. Moreover, the number and kinds of misreadings, mistakes, misunderstandings, and omissions are so extensive that even a brief attempt to address the main points at issue is no small task. But the primary problem is that the reviewer contends that I say the opposite of what I actually maintain with regard to some of the central claims of the book. These mistaken assertions are primarily the consequence of a failure to understand crucial philosophical concepts (especially metaphysical nondualism, being-in-the-world, intentionality, and disclosure). But they also stem from a series of errors ranging from the exclusion of some of the fundamental ideas and arguments of the book to the misreading of pivotal claims and the mistranslation of the Japanese-language primary sources.I begin with a single but telling example that is characteristic of the way the reviewer repeatedly portrays me as saying the opposite of what I actually say. Droz states that “For Johnson, while human beings taken collectively as a whole have the capacity to transcend the fūdo, individual human beings apparently do not” (Droz, 133). But what I actually say is that Watsuji “has not shown that this same capacity belongs to the individual human being” (Johnson, 191). I then give a series of examples of individual transcendence: “the forms of transcendence that are evident in, for example, the complex identities of immigrants, of those who have lived in multiple countries, of those who live in multiple milieus at the same time [...] of those who develop a very different character from their compatriots even as they live together in the same place” (Johnson, 191). [End Page 167] I go on to point out that “we also need a subtler account, on a much smaller scale, of the ways the self is both constituted by and is also able to transcend its fūdo. In what follows we will give an indication of some of the issues involved” (Johnson, 191). I then proceed to give such an overview, concluding with the point that “the strong identification with one aspect of one’s milieu rather than another shows that the self is much more than the simple expression of its fūdo. This form of transcendence, I suggest, can be studied with profit as an instance of what Watsuji calls the individual dimension of human beings” (Johnson, 192).Misrepresentations of this sort abound. The most serious instance of this kind concerns one of the central theses of this study. At the beginning of her review, the author purports to recount two criteria that I propose “to clarify what the philosophical concept of fūdo entails” (Droz, 129). But in fact, I list four criteria under two distinct categories. First, in order to determine the scope and boundaries of a fūdo, I propose the following two criteria:1. certain regions as articulated wholes found in nature itself, which is what Watsuji attempts to articulate with his taxonomy of basic types of fūdo (Johnson, 34).2. a relational whole of disclosure, self-interpretation, and natural locale (Johnson, 34).But the reviewer takes note of (1) and passes over (2) in silence—this omission is significant and, as we will see shortly, it leads her into later difficulties. Droz instead moves directly to a second topic, namely, what I intend by the term nature, which is a concept found in both of these criteria. Here I follow Mill in thinking that we need some way to distinguish between nature and nonnature if nature is not simply to be equated with everything. I therefore propose two criteria that we might use to distinguish nature from artifice within a fūdo: A. nature as all-encompassing space and place B. the sheerly given self-unfolding of things . (shrink)

In lieu of an abstract, here is the first paragraph: Paksi and Héder’s Guide to Personal Knowledge (hereafter GPK and Guide) is, as the title suggests, a guide of the most important and original ideas of Michael Polanyi’s book Personal Knowledge: Towards a Post-Critical Philosophy (1958, hereafter PK). Is a guide to Personal Knowledge needed? I think the answer is a resounding “yes” for many new readers. To see why, let’s briefly review two common complaints about PK.

Evolution is frequently concentrated in bursts of rapid morphological change and speciation followed by long‐term stasis. We propose that this pattern of punctuated equilibria results from an evolutionary tug‐of‐war between host genomes and transposable elements (TEs) mediated through the epigenome. According to this hypothesis, epigenetic regulatory mechanisms (RNA interference, DNA methylation and histone modifications) maintain stasis by suppressing TE mobilization. However, physiological stress, induced by climate change or invasion of new habitats, disrupts epigenetic regulation and unleashes TEs. With their capacity (...) to drive non‐adaptive host evolution, mobilized TEs can restructure the genome and displace populations from adaptive peaks, thus providing an escape from stasis and generating genetic innovations required for rapid diversification. This “epi‐transposon hypothesis” can not only explain macroevolutionary tempo and mode, but may also resolve other long‐standing controversies, such as Wright's shifting balance theory, Mayr's peripheral isolates model, and McClintock's view of genome restructuring as an adaptive response to challenge. (shrink)

Take a hypothetical sequence of human beings ordered by height from tallest to shortest. Make sure there is no more than a difference of a millimeter between each person and make sure the tallest person is clearly tall and the shortest person is clearly not tall. Now consider the following argument: P1 A person of height n is tall ; P2 For any height n, if n is tall, then n–1mm is tall ; C Therefore, a person of height n (...) = 1mm is tall. P1 and P2 are intuitively true, C is intuitively false, yet the argument is deductively valid (the conclusion follows... (shrink)

John Dewey viewed philosophy as an intelligent means of realizing change, emphasizing the ubiquity of process, context and relations. The revolution in Organizational Behavior known as Process Re-engineering (PR) is an approach to organizational thinking recognizing the importance of process, context and relations at all levels of organizational activity. Because Dewey’s philosophy affords primacy to process and change, context and relations, it is fundamentally aligned with PR. Compelling connections between PR and Dewey’s philosophy are established concerning primacy of process, importance (...) of context, inquiry as experimental, value dimensions of outcomes, work as a means to self-realization, and increasing recognition of the future as an open possibility. While Dewey’s philosophy and PR stand as examples of intelligent understanding and reconstruction of process, recent developments in formal systems ontology point to dangerous consequences resulting from an eclipse of the material conditions of experience through the imposition of a formal architectonic. (shrink)

Causation is important when considering how an organism maintains health, why disease arises in a healthy person, and how one may intervene to change the course of a disease. This paper explores the form of causative relationships in health, disease and intervention, with particular regard to the pathological and biopsychosocial models. Consistent with the philosophical view of dispositionalism, we believe that objects are the fundamental relata of causation. By accepting the broad scope of the biopsychosocial model, we argue that psychological (...) and social constructs be considered objects. We think that this 'biopsychosocial dispositionalism' offers the flexibility required to describe causation throughout health, disease and intervention pathways. When constructing mechanistic chains to describe causative pathways, we argue that an object will causally connect with others through actions; transfers of energy from one object to another, initiated by the manifestation of one or more dispositional property. Finally, our analysis of causative interactions utilises the concept that a common form of interaction exists between disease and intervention pathways. This common form will always be an object, but the mode of interaction will vary with each disease. We describe how intervention may act through objects being shared between converging mechanistic chains, or through the removal and/or insertion of objects in such chains. We believe that this analysis provides novel insight to the forms of causative transactions that can occur. In addition, we hope that the findings of this analysis represent the first step towards developing a framework for appraising the composition of mechanistic theories. (shrink)

While a number of classical pragmatists crafted their philosophies in conjunction with a careful study of Hegel's works, others saw their philosophies emerge in antagonism with proponents of Hegel. In this paper, we offer an instance of the latter case. Namely, we show that the impetus for Charles S. Peirce's early articulation and avowal of realism (the claim that some generals are real) was William Torrey Harris's claim that the formal laws of logic lacked universal validity. According to Harris, the (...) leading representative of Hegelism in the United States, the universal validity of the laws of logic rested on a nominalistic metaphysics that a Hegelian-realism showed to be false. In response to this charge, we articulate how Peirce's attempt to prove the universal validity of the laws of logic resulted in avowing a realism that differed from both nominalism and Harris's Hegelian-realism. (shrink)

Cooperative learning processes have been rediscovered and are being used throughout the country on every level. The basic elements of cooperative goal structure are positive interdependence, individual accountability, face-to-face interaction, and cooperative skills. The teacher's role in structuring cooperative learning situations involves clearly specifying lesson objectives, placing students in productive learning groups and providing appropriate materials, clearly explaining the cooperative goal structure, monitoring students, and evaluating performance. For cooperative learning groups to be productive, students must be able to engage in (...) the needed collaborative skills. Cooperative skills and academic skills can be taught simultaneously. The implementation of cooperative learning needs to be coupled with the implementation of collaborative professional support groups among educators. Both the success of implementation efforts and the quality of life within most schools depend on teachers and other staff members cooperating with each other. Support for the program takes as careful structuring and monitoring as does cooperative learning. (JD). (shrink)

Unabridged dictionaries are dangerous books. In their pages man’s evilest thoughts find means of expression. Terms denoting all that is foul or blasphemous or obscene are printed there for men, women and children to read and ponder. Such books should have their covers padlocked and be chained to reading desks, in the custody of responsible librarians, preferably church members in good standing. Permission to open such books should be granted only after careful inquiry as to which word a reader plans (...) to look up, and how he plans to use it. (shrink)

Some philosophers have argued recently that the content of perception is either entirely or mainly non- conceptual. Much of the motivation for that view derives from theories of information processing, which are a modern version of ancient considerations about the causal processes underlying perception. The paper argues to the contrary that perception is essentially concept- dependent. While perception must have a structure derived from what is purely sensory, and is thereby dependent on processes involving information in the technical sense which (...) Gibson said amounted to structure, the information which perception provides about the world depends on the concepts which we have. (shrink)

Hume: General Philosophy makes available the most significant essays published on the work of David Hume. It brings together an extensive array of often difficult to obtain essays in a convenient and accessible format for researchers, teachers and student alike. Featuring a full-length introduction form the editor, it is an indispensable international reference work.

Despite the importance of linguistic disclosure for philosophical hermeneutics there has been a conspicuous lack of attention to the question of how linguistic disclosure actually works. I examine the mechanics of disclosure by drawing on Gadamer’s philosophical hermeneutics as well as Ricoeur’s concept of translation and his theory of metaphor. My claim is that the background horizon of the unsaid that differs between languages enables each to disclose different things. This situation underscores the importance of engaging in East-West comparative philosophy, (...) of philosophizing across what Ricoeur calls the radical “fold” (pli) in what can be thought and experienced. (shrink)

During the past several decades, a number of accounts of environmental and ethnic wisdom have appeared which have later been exposed as fraudulent. The widespread popularity of these accounts should be understood as symptomatic of valid feelings and awarenesses that are unable to find expression in the modern world, and are usually dissociated from mainstream decision-making processes. As the natural order continues to be degraded, forms such as fiction which currently have relatively low status will become more important as vehicles (...) for feelings, ideas, and possibilities which can find no other refuge within a world increasingly dominated by technological and economic viewpoints. (shrink)

Psychology, often defined as the science of human behavior, has so far had little to say about the environmental destruction which is currently occurring as the result of human behavior. I consider the reasons why it has not and suggest that the ideological preconceptions that underpin the discipline are similar to those of the technological-economic system that is largely responsible for degradation ofthe environment. Psychology, by normalizing the behavioral, life-style, and personality configurations associated with environmental destruction, and lacking a historical (...) perspective on changes in consciousness and technology, is unable to contribute effectively to the ecological debate. I conclude that the discipline needs to locate itself historically and ideologically before it can offer an adequate analysis of environmental destruction. (shrink)

Mother and Fetus: Rights in Conflict A. INTRODUCTION After fertilization of the female egg (ovum) with male sperm the resulting zygote may implant ...

If we want to see justice done with regard to responsibility, then we must either (i) allow that people are never morally responsible, (iia) show that luck is not ubiquitous or at least that (iib) ubiquitous luck is not moral, or (iii) show that ascriptions of responsibility can retain justice despite the omnipresence of luck. This paper defends (iii); ascriptions of responsibility can be just even though luck is ubiquitous.

This paper articulates and defends a noncognitive, care-based view of identification, of what privileged psychic subset provides the source of self-determination in actions and attitudes. The author provides an extended analysis of "caring," and then applies it to debates between Frankfurtians, on the one hand, and Watsonians, on the other, about the nature of identification, then defends the view against objections.